Cholinergic Modulation of Narcoleptic Attacks in Double Orexin Receptor Knockout Mice

To investigate how cholinergic systems regulate aspects of the sleep disorder narcolepsy, we video-monitored mice lacking both orexin (hypocretin) receptors (double knockout; DKO mice) while pharmacologically altering cholinergic transmission. Spontaneous behavioral arrests in DKO mice were highly s...

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Autors principals: Kalogiannis, Mike, Hsu, Emily, Willie, Jon T., Chemelli, Richard M., Kisanuki, Yaz Y., Yanagisawa, Masashi, Leonard, Christopher S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076437/
https://ncbi.nlm.nih.gov/pubmed/21533254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018697
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