Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma

Chemoprevention of head and neck squamous cell carcinoma (HNSCC), a disease associated with high mortality rates and frequent occurrence of second primary tumor (SPT), is an important clinical goal. The epidermal growth factor receptor (EGFR)-signal transducer and activator of transcription (STAT)-3...

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Hauptverfasser: Leeman-Neill, Rebecca J., Seethala, Raja R., Singh, Shivendra V., Freilino, Maria L., Bednash, Joseph S., Thomas, Sufi M., Panahandeh, Mary C., Gooding, William E., Joyce, Sonali C., Lingen, Mark W., Neill, Daniel B., Grandis, Jennifer R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076320/
https://ncbi.nlm.nih.gov/pubmed/21163936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0249
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