Identification of miR-34a as a potent inhibitor of prostate cancer progenitor cells and metastasis by directly repressing CD44

Cancer stem cells (CSCs) or tumor progenitor cells are involved in tumor progression and metastasis1. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs2–5 and miRNA dysregulation has been implicated in tumorigenesis6. CSCs in many tumors, including cancers of the breast7, pancreas8, head a...

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Bibliografiske detaljer
Main Authors: Liu, Can, Kelnar, Kevin, Liu, Bigang, Chen, Xin, Calhoun-Davis, Tammy, Li, Hangwen, Patrawala, Lubna, Yan, Hong, Jeter, Collene, Honorio, Sofia, Wiggins, Jason F., Bader, Andreas G., Fagin, Randy, Brown, David, Tang, Dean G.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076220/
https://ncbi.nlm.nih.gov/pubmed/21240262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2284
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