NANOG reprograms prostate cancer cells to castration resistance via dynamically repressing and engaging the AR/FOXA1 signaling axis

The pluripotency transcription factor NANOG has been implicated in tumor development, and NANOG-expressing cancer cells manifest stem cell properties that sustain tumor homeostasis, mediate therapy resistance and fuel tumor progression. However, how NANOG converges on somatic circuitry to trigger on...

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Vydáno v:Cell Discov
Hlavní autoři: Jeter, Collene R, Liu, Bigang, Lu, Yue, Chao, Hsueh-Ping, Zhang, Dingxiao, Liu, Xin, Chen, Xin, Li, Qiuhui, Rycaj, Kiera, Calhoun-Davis, Tammy, Yan, Li, Hu, Qiang, Wang, Jianmin, Shen, Jianjun, Liu, Song, Tang, Dean G
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109294/
https://ncbi.nlm.nih.gov/pubmed/27867534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.41
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