Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses

Expression of androgen receptor (AR) in prostate cancer (PCa) is heterogeneous but the functional significance of AR heterogeneity remains unclear. Screening ~200 castration-resistant PCa (CRPC) cores and whole-mount sections (from 89 patients) reveals 3 AR expression patterns: nuclear (nuc-AR), mix...

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Publié dans:Nat Commun
Auteurs principaux: Li, Qiuhui, Deng, Qu, Chao, Hsueh-Ping, Liu, Xin, Lu, Yue, Lin, Kevin, Liu, Bigang, Tang, Gregory W., Zhang, Dingxiao, Tracz, Amanda, Jeter, Collene, Rycaj, Kiera, Calhoun-Davis, Tammy, Huang, Jiaoti, Rubin, Mark A., Beltran, Himisha, Shen, Jianjun, Chatta, Gurkamal, Puzanov, Igor, Mohler, James L., Wang, Jianmin, Zhao, Ruizhe, Kirk, Jason, Chen, Xin, Tang, Dean G.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127155/
https://ncbi.nlm.nih.gov/pubmed/30190514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06067-7
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