Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses

Expression of androgen receptor (AR) in prostate cancer (PCa) is heterogeneous but the functional significance of AR heterogeneity remains unclear. Screening ~200 castration-resistant PCa (CRPC) cores and whole-mount sections (from 89 patients) reveals 3 AR expression patterns: nuclear (nuc-AR), mix...

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Publicado no:Nat Commun
Main Authors: Li, Qiuhui, Deng, Qu, Chao, Hsueh-Ping, Liu, Xin, Lu, Yue, Lin, Kevin, Liu, Bigang, Tang, Gregory W., Zhang, Dingxiao, Tracz, Amanda, Jeter, Collene, Rycaj, Kiera, Calhoun-Davis, Tammy, Huang, Jiaoti, Rubin, Mark A., Beltran, Himisha, Shen, Jianjun, Chatta, Gurkamal, Puzanov, Igor, Mohler, James L., Wang, Jianmin, Zhao, Ruizhe, Kirk, Jason, Chen, Xin, Tang, Dean G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127155/
https://ncbi.nlm.nih.gov/pubmed/30190514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06067-7
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