Functional Evidence that the Self-Renewal Gene NANOG Regulates Human Tumor Development

Tumor development has long been known to resemble abnormal embryogenesis. The embryonic stem cell (ESC) self-renewal gene NANOG is purportedly expressed by some epithelial cancer cells but a causal role in tumor development has remained unclear. Here, we provide compelling evidence that cultured can...

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Main Authors: Jeter, Collene R., Badeaux, Mark, Choy, Grace, Chandra, Dhyan, Patrawala, Lubna, Liu, Can, Calhoun-Davis, Tammy, Zaehres, Holm, Daley, George Q., Tang, Dean G.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327393/
https://ncbi.nlm.nih.gov/pubmed/19415763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.29
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