SCF(Fbw7) Regulates Cellular Apoptosis By Targeting Mcl-1 for Ubiquitination and Destruction

The effective use of targeted therapy is highly dependent upon the identification of responder patient populations. Loss of the Fbw7 tumor suppressor is frequently found in various types of human cancers including breast cancer, colon cancer 1 and T-cell acute lymphoblastic leukemia (T-ALL)2. In lin...

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Main Authors: Inuzuka, Hiroyuki, Shaik, Shavali, Onoyama, Ichiro, Gao, Daming, Tseng, Alan, Maser, Richard S., Zhai, Bo, Wan, Lixin, Gutierrez, Alejandro, Lau, Alan W., Xiao, Yonghong, Christie, Amanda L., Aster, Jon, Settleman, Jeffrey, Gygi, Steven P., Kung, Andrew L., Look, Thomas, Nakayama, Keiichi I., DePinho, Ronald A., Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076007/
https://ncbi.nlm.nih.gov/pubmed/21368833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09732
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