SCF(Fbw7) Regulates Cellular Apoptosis By Targeting Mcl-1 for Ubiquitination and Destruction

The effective use of targeted therapy is highly dependent upon the identification of responder patient populations. Loss of the Fbw7 tumor suppressor is frequently found in various types of human cancers including breast cancer, colon cancer 1 and T-cell acute lymphoblastic leukemia (T-ALL)2. In lin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Inuzuka, Hiroyuki, Shaik, Shavali, Onoyama, Ichiro, Gao, Daming, Tseng, Alan, Maser, Richard S., Zhai, Bo, Wan, Lixin, Gutierrez, Alejandro, Lau, Alan W., Xiao, Yonghong, Christie, Amanda L., Aster, Jon, Settleman, Jeffrey, Gygi, Steven P., Kung, Andrew L., Look, Thomas, Nakayama, Keiichi I., DePinho, Ronald A., Wei, Wenyi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076007/
https://ncbi.nlm.nih.gov/pubmed/21368833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09732
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