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A new 2'-hydroxyl protecting group for the automated synthesis of oligoribonucleotides.

We have developed a new type of 2'-hydroxyl protecting group for the automated machine synthesis of RNA oligomers: a 2-hydroxyisophthalate formaldehyde acetal (HIFA). The unique feature of this protecting group is that, as the bis ester, it is relatively stable to the acidic conditions that are...

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Detaylı Bibliyografya
Asıl Yazarlar: Rastogi, H, Usher, D A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1995
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC307477/
https://ncbi.nlm.nih.gov/pubmed/8532531
Etiketler: Etiketle
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