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A new 2'-hydroxyl protecting group for the automated synthesis of oligoribonucleotides.
We have developed a new type of 2'-hydroxyl protecting group for the automated machine synthesis of RNA oligomers: a 2-hydroxyisophthalate formaldehyde acetal (HIFA). The unique feature of this protecting group is that, as the bis ester, it is relatively stable to the acidic conditions that are...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1995
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC307477/ https://ncbi.nlm.nih.gov/pubmed/8532531 |
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