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A new 2'-hydroxyl protecting group for the automated synthesis of oligoribonucleotides.

We have developed a new type of 2'-hydroxyl protecting group for the automated machine synthesis of RNA oligomers: a 2-hydroxyisophthalate formaldehyde acetal (HIFA). The unique feature of this protecting group is that, as the bis ester, it is relatively stable to the acidic conditions that are...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Rastogi, H, Usher, D A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1995
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307477/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8532531/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.23.4872
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