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5'-Levulinyl and 2'-tetrahydrofuranyl protection for the synthesis of oligoribonucleotides by the phosphoramidite approach.

The levulinyl group has been employed for protection of the 5'-hydroxyl group in the synthesis of oligoribonucleotides by the phosphoramidite approach, using the acid-labile 2'-tetrahydro-furanyl group. The hydrazine treatment was performed for 10 minutes in order to remove the levulinyl g...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Iwai, S, Ohtsuka, E
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 1988
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC338755/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3186438/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/16.20.9443
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