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Synthesis of 2'-modified nucleotides and their incorporation into hammerhead ribozymes.

Several 2'-modified ribonucleoside phosphoramidites have been prepared for structure-activity studies of the hammerhead ribozyme. The aim of these studies was to design and synthesize catalytically active and nuclease-resistant ribozymes. Synthetic schemes for stereoselective synthesis of the R...

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Bibliografiske detaljer
Main Authors: Beigelman, L, Karpeisky, A, Matulic-Adamic, J, Haeberli, P, Sweedler, D, Usman, N
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC307401/
https://ncbi.nlm.nih.gov/pubmed/7501467
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