Synthesis of 2'-modified nucleotides and their incorporation into hammerhead ribozymes.

Several 2'-modified ribonucleoside phosphoramidites have been prepared for structure-activity studies of the hammerhead ribozyme. The aim of these studies was to design and synthesize catalytically active and nuclease-resistant ribozymes. Synthetic schemes for stereoselective synthesis of the R isom...

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Publicado en:	Nucleic Acids Res
Autores principales:	Beigelman, L, Karpeisky, A, Matulic-Adamic, J, Haeberli, P, Sweedler, D, Usman, N
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 1995
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307401/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7501467/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.21.4434
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