Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases.
We have synthesized 13 hammerhead ribozyme variants, each containing an abasic residue at a specific position of the catalytic core. The activity of each of the variants is significantly reduced. In four cases, however, activity can be rescued by exogenous addition of the missing base. For one varia...
Zapisane w:
| Wydane w: | Proc Natl Acad Sci U S A |
|---|---|
| Główni autorzy: | , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
1996
|
| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8876168/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.21.11522 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|