Design and Synthesis of an Orally Active Metabotropic Glutamate Receptor Subtype-2 (mGluR2) Positive Allosteric Modulator (PAM) that Decreases Cocaine Self-administration in Rats

The modification of 3′-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yloxy)methyl)biphenyl-4-carboxylic acid (BINA, 1) by incorporating heteroatoms into the structure and replacing the cyclopentyl moiety led to the development of new mGluR2 positive allosteric modulators (PAMs) with opti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Dhanya, Raveendra-Panickar, Sidique, Shyama, Sheffler, Douglas J., Nickols, Hilary Highfield, Herath, Ananda, Yang, Li, Dahl, Russell, Ardecky, Robert, Semenova, Svetlana, Markou, Athina, Conn, P. Jeffrey, Cosford, Nicholas D. P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071440/
https://ncbi.nlm.nih.gov/pubmed/21155570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1012165
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge