Design and Synthesis of an Orally Active Metabotropic Glutamate Receptor Subtype-2 (mGluR2) Positive Allosteric Modulator (PAM) that Decreases Cocaine Self-administration in Rats

The modification of 3′-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yloxy)methyl)biphenyl-4-carboxylic acid (BINA, 1) by incorporating heteroatoms into the structure and replacing the cyclopentyl moiety led to the development of new mGluR2 positive allosteric modulators (PAMs) with opti...

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Detalhes bibliográficos
Main Authors: Dhanya, Raveendra-Panickar, Sidique, Shyama, Sheffler, Douglas J., Nickols, Hilary Highfield, Herath, Ananda, Yang, Li, Dahl, Russell, Ardecky, Robert, Semenova, Svetlana, Markou, Athina, Conn, P. Jeffrey, Cosford, Nicholas D. P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071440/
https://ncbi.nlm.nih.gov/pubmed/21155570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1012165
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