Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype-2 and -3 (mGlu(2/3)) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence

[Image: see text] As part of our ongoing small-molecule metabotropic glutamate (mGlu) receptor positive allosteric modulator (PAM) research, we performed structure–activity relationship (SAR) studies around a series of group II mGlu PAMs. Initial analogues exhibited weak activity as mGlu(2) receptor...

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Detalhes bibliográficos
Main Authors: Dhanya, Raveendra-Panickar, Sheffler, Douglas J., Dahl, Russell, Davis, Melinda, Lee, Pooi San, Yang, Li, Nickols, Hilary Highfield, Cho, Hyekyung P., Smith, Layton H., D’Souza, Manoranjan S., Conn, P. Jeffrey, Der-Avakian, Andre, Markou, Athina, Cosford, Nicholas D. P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033659/
https://ncbi.nlm.nih.gov/pubmed/24735492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5000563
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