Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure-Activity Relationships and Assessment in a Rat Model of Nicotine Dependence

Compounds that modulate metabotropic glutamate subtype 2 (mGlu(2)) receptors have the potential to treat several disorders of the central nervous system (CNS) including drug dependence. Herein we describe the synthesis and structure-activity relationship (SAR) studies around a series of mGlu(2) rece...

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Autors principals: Sidique, Shyama, Dhanya, Raveendra-Panickar, Sheffler, Douglas J., Nickols, Hilary Highfield, Yang, Li, Dahl, Russell, Mangravita-Novo, Arianna, Smith, Layton H., D’Souza, Manoranjan S., Semenova, Svetlana, Conn, P. Jeffrey, Markou, Athina, Cosford, Nicholas D. P.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508153/
https://ncbi.nlm.nih.gov/pubmed/23009245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3005306
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