A Combination of Flow and Batch Mode Processes for the Efficient Preparation of mGlu(2/3) Receptor Negative Allosteric Modulators (NAMs)

Benzodiazepinones are privileged scaffolds with activity against multiple therapeutically relevant biological targets. In support of our ongoing studies around allosteric modulators of metabotropic glutamate receptors (mGlus) we required the multigram synthesis of a β-ketoester key intermediate. We...

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Bibliografiska uppgifter
I publikationen:Tetrahedron
Huvudupphovsmän: Dhanya, Raveendra Panickar, Herath, Ananda, Sheffler, Douglas J., Cosford, Nicholas D. P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349389/
https://ncbi.nlm.nih.gov/pubmed/30705468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2018.03.068
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