mGlu(2) and mGlu(3) negative allosteric modulators divergently potentiate thalamocortical transmission and exert rapid antidepressant-like effects

Non-selective antagonists of metabotropic glutamate receptor subtypes 2 (mGlu(2)) and 3 (mGlu(3)) exert rapid antidepressant-like effects by enhancing prefrontal cortex (PFC) glutamate transmission, however the receptor subtype contributions and underlying mechanisms remain unclear. Here, we leverag...

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Udgivet i:Neuron
Main Authors: Joffe, Max E., Santiago, Chiaki I., Oliver, Kendra H., Maksymetz, James, Harris, Nicholas A., Engers, Julie L., Lindsley, Craig W., Winder, Danny G., Conn, P. Jeffrey
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952546/
https://ncbi.nlm.nih.gov/pubmed/31735403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.09.044
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