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A Combination of Flow and Batch Mode Processes for the Efficient Preparation of mGlu(2/3) Receptor Negative Allosteric Modulators (NAMs)
Benzodiazepinones are privileged scaffolds with activity against multiple therapeutically relevant biological targets. In support of our ongoing studies around allosteric modulators of metabotropic glutamate receptors (mGlus) we required the multigram synthesis of a β-ketoester key intermediate. We...
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| Publicado no: | Tetrahedron |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6349389/ https://ncbi.nlm.nih.gov/pubmed/30705468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2018.03.068 |
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