The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats

Metabotropic glutamate receptor 2/3 (mGluR2/3) agonists were shown previously to nonselectively decrease both cocaine- and food-maintained responding in rats. mGluR2 positive allosteric modulators (PAMs) may represent improved therapeutic compounds because of their modulatory properties and higher s...

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Autores principales: Jin, Xinchun, Semenova, Svetlana, Yang, Li, Ardecky, Robert, Sheffler, Douglas J, Dahl, Russell, Conn, P Jeffrey, Cosford, Nicholas DP, Markou, Athina
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922422/
https://ncbi.nlm.nih.gov/pubmed/20555310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.82
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