Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form the mucus gel layer overlying the gut epithelium. Impaired expression of intestinal O-glycans has been observed in patients with ulcerative colitis (UC), but its role in the etiology of this di...

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Bibliografische gegevens
Hoofdauteurs: Fu, Jianxin, Wei, Bo, Wen, Tao, Johansson, Malin E.V., Liu, Xiaowei, Bradford, Emily, Thomsson, Kristina A., McGee, Samuel, Mansour, Lilah, Tong, Maomeng, McDaniel, J. Michael, Sferra, Thomas J., Turner, Jerrold R., Chen, Hong, Hansson, Gunnar C., Braun, Jonathan, Xia, Lijun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2011
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069788/
https://ncbi.nlm.nih.gov/pubmed/21383503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45538
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