Core 1- and core 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice

Core 1- and core 3-derived mucin-type O-glycans are primary components of the mucus layer in the colon. Reduced mucus thickness and impaired O-glycosylation are observed in human ulcerative colitis. However, how both types of O-glycans maintain mucus barrier function in the colon is unclear. We foun...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Bergstrom, Kirk, Fu, Jianxin, Johansson, Malin EV, Liu, Xiaowei, Gao, Nan, Wu, Qian, Song, Jianhua, McDaniel, J Michael, McGee, Samuel, Chen, Weichang, Braun, Jonathan, Hansson, Gunnar C, Xia, Lijun
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097036/
https://ncbi.nlm.nih.gov/pubmed/27143302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2016.45
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