Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form the mucus gel layer overlying the gut epithelium. Impaired expression of intestinal O-glycans has been observed in patients with ulcerative colitis (UC), but its role in the etiology of this di...

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Main Authors: Fu, Jianxin, Wei, Bo, Wen, Tao, Johansson, Malin E.V., Liu, Xiaowei, Bradford, Emily, Thomsson, Kristina A., McGee, Samuel, Mansour, Lilah, Tong, Maomeng, McDaniel, J. Michael, Sferra, Thomas J., Turner, Jerrold R., Chen, Hong, Hansson, Gunnar C., Braun, Jonathan, Xia, Lijun
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069788/
https://ncbi.nlm.nih.gov/pubmed/21383503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45538
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