Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form the mucus gel layer overlying the gut epithelium. Impaired expression of intestinal O-glycans has been observed in patients with ulcerative colitis (UC), but its role in the etiology of this di...

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Detalhes bibliográficos
Main Authors: Fu, Jianxin, Wei, Bo, Wen, Tao, Johansson, Malin E.V., Liu, Xiaowei, Bradford, Emily, Thomsson, Kristina A., McGee, Samuel, Mansour, Lilah, Tong, Maomeng, McDaniel, J. Michael, Sferra, Thomas J., Turner, Jerrold R., Chen, Hong, Hansson, Gunnar C., Braun, Jonathan, Xia, Lijun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069788/
https://ncbi.nlm.nih.gov/pubmed/21383503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45538
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