Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease

Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via the transcriptional dysregulation of a number of genes, including those involved in mitochondrial biogenesis. Here we show that transglutaminase 2, which is upregulated in HD,...

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Detalhes bibliográficos
Main Authors: McConoughey, Stephen J, Basso, Manuela, Niatsetskaya, Zoya V, Sleiman, Sama F, Smirnova, Natalia A, Langley, Brett C, Mahishi, Lata, Cooper, Arthur J L, Antonyak, Marc A, Cerione, Rick A, Li, Bo, Starkov, Anatoly, Chaturvedi, Rajnish Kumar, Beal, M Flint, Coppola, Giovanni, Geschwind, Daniel H, Ryu, Hoon, Xia, Li, Iismaa, Siiri E, Pallos, Judit, Pasternack, Ralf, Hils, Martin, Fan, Jing, Raymond, Lynn A, Marsh, J Lawrence, Thompson, Leslie M, Ratan, Rajiv R
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068019/
https://ncbi.nlm.nih.gov/pubmed/20665636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201000084
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