Distinct Roles for the NF-κB RelA Subunit during Antiviral Innate Immune Responses

Production of type I interferons (IFNs; prominently, IFN-α/β) following virus infection is a pivotal antiviral innate immune response in higher vertebrates. The synthesis of IFN-β proceeds via the virus-induced assembly of the transcription factors IRF-3/7, ATF-2/c-Jun, and NF-κB on the ifnβ promote...

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Bibliographic Details
Main Authors: Basagoudanavar, Suresh H., Thapa, Roshan J., Nogusa, Shoko, Wang, Junmei, Beg, Amer A., Balachandran, Siddharth
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2011
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067974/
https://ncbi.nlm.nih.gov/pubmed/21209118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02213-10
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