Glycosylphosphatidylinositol Anchor-Dependent Stimulation Pathway Required for Generation of Baculovirus-Derived Recombinant Scrapie Prion Protein

The pathogenic isoform (PrP(Sc)) of the host-encoded cellular prion protein (PrP(C)) is considered to be an infectious agent of transmissible spongiform encephalopathy (TSE). The detailed mechanism by which the PrP(Sc) seed catalyzes the structural conversion of endogenous PrP(C) into nascent PrP(Sc...

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Autores principales: Imamura, Morikazu, Kato, Nobuko, Yoshioka, Miyako, Okada, Hiroyuki, Iwamaru, Yoshifumi, Shimizu, Yoshihisa, Mohri, Shirou, Yokoyama, Takashi, Murayama, Yuichi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2011
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067941/
https://ncbi.nlm.nih.gov/pubmed/21228241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02098-10
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