Glycosylphosphatidylinositol Anchor-Dependent Stimulation Pathway Required for Generation of Baculovirus-Derived Recombinant Scrapie Prion Protein

The pathogenic isoform (PrP(Sc)) of the host-encoded cellular prion protein (PrP(C)) is considered to be an infectious agent of transmissible spongiform encephalopathy (TSE). The detailed mechanism by which the PrP(Sc) seed catalyzes the structural conversion of endogenous PrP(C) into nascent PrP(Sc...

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Библиографические подробности
Главные авторы: Imamura, Morikazu, Kato, Nobuko, Yoshioka, Miyako, Okada, Hiroyuki, Iwamaru, Yoshifumi, Shimizu, Yoshihisa, Mohri, Shirou, Yokoyama, Takashi, Murayama, Yuichi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2011
Предметы:
Pathogenesis and Immunity
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067941/
https://ncbi.nlm.nih.gov/pubmed/21228241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02098-10
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