Insect Cell-Derived Cofactors Become Fully Functional after Proteinase K and Heat Treatment for High-Fidelity Amplification of Glycosylphosphatidylinositol-Anchored Recombinant Scrapie and BSE Prion Proteins

The central event in prion infection is the conformational conversion of host-encoded cellular prion protein (PrP(C)) into the pathogenic isoform (PrP(Sc)). Diverse mammalian species possess the cofactors required for in vitro replication of PrP(Sc) by protein-misfolding cyclic amplification (PMCA),...

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Detalhes bibliográficos
Main Authors: Imamura, Morikazu, Kato, Nobuko, Okada, Hiroyuki, Yoshioka, Miyako, Iwamaru, Yoshifumi, Shimizu, Yoshihisa, Mohri, Shirou, Yokoyama, Takashi, Murayama, Yuichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867355/
https://ncbi.nlm.nih.gov/pubmed/24367521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082538
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