Glycosylphosphatidylinositol Anchor-Dependent Stimulation Pathway Required for Generation of Baculovirus-Derived Recombinant Scrapie Prion Protein

The pathogenic isoform (PrP(Sc)) of the host-encoded cellular prion protein (PrP(C)) is considered to be an infectious agent of transmissible spongiform encephalopathy (TSE). The detailed mechanism by which the PrP(Sc) seed catalyzes the structural conversion of endogenous PrP(C) into nascent PrP(Sc...

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Detalhes bibliográficos
Main Authors: Imamura, Morikazu, Kato, Nobuko, Yoshioka, Miyako, Okada, Hiroyuki, Iwamaru, Yoshifumi, Shimizu, Yoshihisa, Mohri, Shirou, Yokoyama, Takashi, Murayama, Yuichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067941/
https://ncbi.nlm.nih.gov/pubmed/21228241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02098-10
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