Single base discrimination for ribonuclease H-dependent antisense effects within intact human leukaemia cells.

We have previously demonstrated, in vitro, that phosphodiester and phosphorothioate antisense oligodeoxynucleotides could direct ribonuclease H to cleave non-target RNA sites and that chimeric methylphosphonodiester/phosphodiester analogue structures were substantially more specific. In this report...

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Bibliografiske detaljer
Main Authors:	Giles, R V, Ruddell, C J, Spiller, D G, Green, J A, Tidd, D M
Format:	Artigo
Sprog:	Inglês
Udgivet:	1995
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC306791/ https://ncbi.nlm.nih.gov/pubmed/7731809
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Single base discrimination for ribonuclease H-dependent antisense effects within intact human leukaemia cells.

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