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Single base discrimination for ribonuclease H-dependent antisense effects within intact human leukaemia cells.

We have previously demonstrated, in vitro, that phosphodiester and phosphorothioate antisense oligodeoxynucleotides could direct ribonuclease H to cleave non-target RNA sites and that chimeric methylphosphonodiester/phosphodiester analogue structures were substantially more specific. In this report...

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書目詳細資料
發表在:Nucleic Acids Res
Principais autores: Giles, R V, Ruddell, C J, Spiller, D G, Green, J A, Tidd, D M
格式: Artigo
語言:Inglês
出版: Oxford University Press 1995
在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306791/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7731809/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.6.954
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