Single base discrimination for ribonuclease H-dependent antisense effects within intact human leukaemia cells.

We have previously demonstrated, in vitro, that phosphodiester and phosphorothioate antisense oligodeoxynucleotides could direct ribonuclease H to cleave non-target RNA sites and that chimeric methylphosphonodiester/phosphodiester analogue structures were substantially more specific. In this report...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Giles, R V, Ruddell, C J, Spiller, D G, Green, J A, Tidd, D M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1995
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306791/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7731809/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.6.954
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