Autophagy Deficiency Promotes β-Lactam Production in Penicillium chrysogenum

We have investigated the significance of autophagy in the production of the β-lactam antibiotic penicillin (PEN) by the filamentous fungus Penicillium chrysogenum. In this fungus PEN production is compartmentalized in the cytosol and in peroxisomes. We demonstrate that under PEN-producing conditions...

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Bibliographic Details
Main Authors: Bartoszewska, Magdalena, Kiel, Jan A. K. W., Bovenberg, Roel A. L., Veenhuis, Marten, van der Klei, Ida J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2011
Subjects:
Mycology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067201/
https://ncbi.nlm.nih.gov/pubmed/21169429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01531-10
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