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P53 impairs endothelial function by transcriptionally repressing Kruppel-like factor 2
OBJECTIVE: Endothelial Kruppel-like factor 2 (KLF2) mediates endothelium-dependent vascular homeostasis by differentially regulating endothelial genes, leading to an anti-inflammatory and anti-thrombotic endothelial surface with normal vasodilatory function. In contrast, the tumor suppressor p53 lea...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064482/ https://ncbi.nlm.nih.gov/pubmed/20947822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.215061 |
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