Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy

Positron emission tomography (PET) is used in drug development to assist dose selection and to establish the relationship between blood and tissue pharmacokinetics (PKs). We present a new biomathematical approach that allows prediction of repeat-dose (RD) brain target occupancy (TO) using occupancy...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Abanades, Sergio, van der Aart, Jasper, Barletta, Julien AR, Marzano, Carmine, Searle, Graham E, Salinas, Cristian A, Ahmad, Javaad J, Reiley, Richard R, Pampols-Maso, Sabina, Zamuner, Stefano, Cunningham, Vincent J, Rabiner, Eugenii A, Laruelle, Marc A, Gunn, Roger N
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2011
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063628/
https://ncbi.nlm.nih.gov/pubmed/20940733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.175
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