Quantification of human brain PDE4 occupancy by GSK356278: A [(11)C](R)-rolipram PET study

We characterized the relationship between the plasma concentration of the phospodiesterase (PDE)-4 inhibitor GSK356278 and occupancy of the PDE4 enzyme in the brain of healthy volunteers, using the positron emission tomography (PET) tracer [(11)C](R)-rolipram. To this end, PET scans were acquired in...

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Bibliografski detalji
Izdano u:J Cereb Blood Flow Metab
Glavni autori: van der Aart, Jasper, Salinas, Cristian, Dimber, Rahul, Pampols-Maso, Sabina, Weekes, Ashley A, Tonkyn, John, Gray, Frank A, Passchier, Jan, Gunn, Roger N, Rabiner, Eugenii A
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2017
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238179/
https://ncbi.nlm.nih.gov/pubmed/28737056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17720868
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