Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy

Positron emission tomography (PET) is used in drug development to assist dose selection and to establish the relationship between blood and tissue pharmacokinetics (PKs). We present a new biomathematical approach that allows prediction of repeat-dose (RD) brain target occupancy (TO) using occupancy...

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Hlavní autoři: Abanades, Sergio, van der Aart, Jasper, Barletta, Julien AR, Marzano, Carmine, Searle, Graham E, Salinas, Cristian A, Ahmad, Javaad J, Reiley, Richard R, Pampols-Maso, Sabina, Zamuner, Stefano, Cunningham, Vincent J, Rabiner, Eugenii A, Laruelle, Marc A, Gunn, Roger N
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063628/
https://ncbi.nlm.nih.gov/pubmed/20940733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.175
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