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Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited
Quantitative estimation of neuroreceptor occupancy by exogenous drugs using positron emission tomography is based on the reduction in the total volume of distribution (V(T)) of site-specific radioligands after drug administration. An estimate of the distribution volume of free and nonspecifically bo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949110/ https://ncbi.nlm.nih.gov/pubmed/19738632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.190 |
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