A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: application to [(11)C]PBR28 and [(18)F]PBR111 for TSPO imaging

Positron emission tomography (PET) radioligands for a reversible central nervous system (CNS) demand a high specific to nonspecific signal characterized by the binding potential (BP(ND)). The quantification of BP(ND) requires the determination of the nondisplaceable binding usually derived from a re...

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Autors principals: Guo, Qi, Owen, David R, Rabiner, Eugenii A, Turkheimer, Federico E, Gunn, Roger N
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083379/
https://ncbi.nlm.nih.gov/pubmed/24736889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.65
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