Two binding sites for [(3)H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation

[(11)C]PBR28, a radioligand targeting the translocator protein (TSPO), does not produce a specific binding signal in approximately 14% of healthy volunteers. This phenomenon has not been reported for [(11)C]PK11195, another TSPO radioligand. We measured the specific binding signals with [(3)H]PK1119...

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Autori principali: Owen, David R, Howell, Owain W, Tang, Sac-Pham, Wells, Lisa A, Bennacef, Idriss, Bergstrom, Mats, Gunn, Roger N, Rabiner, Eugenii A, Wilkins, Martin R, Reynolds, Richard, Matthews, Paul M, Parker, Christine A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949260/
https://ncbi.nlm.nih.gov/pubmed/20424634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.63
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