An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

[(11)C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of signal are confounded by large interindividual variability in binding affinity, which displays a trimodal distribution...

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Bibliografiske detaljer
Main Authors: Owen, David R, Yeo, Astrid J, Gunn, Roger N, Song, Kijoung, Wadsworth, Graham, Lewis, Andrew, Rhodes, Chris, Pulford, David J, Bennacef, Idriss, Parker, Christine A, StJean, Pamela L, Cardon, Lon R, Mooser, Vincent E, Matthews, Paul M, Rabiner, Eugenii A, Rubio, Justin P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Rapid Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323305/
https://ncbi.nlm.nih.gov/pubmed/22008728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.147
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