An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

[(11)C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of signal are confounded by large interindividual variability in binding affinity, which displays a trimodal distribution...

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書誌詳細
主要な著者: Owen, David R, Yeo, Astrid J, Gunn, Roger N, Song, Kijoung, Wadsworth, Graham, Lewis, Andrew, Rhodes, Chris, Pulford, David J, Bennacef, Idriss, Parker, Christine A, StJean, Pamela L, Cardon, Lon R, Mooser, Vincent E, Matthews, Paul M, Rabiner, Eugenii A, Rubio, Justin P
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2012
主題:
Rapid Communication
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323305/
https://ncbi.nlm.nih.gov/pubmed/22008728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.147
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