An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

[(11)C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of signal are confounded by large interindividual variability in binding affinity, which displays a trimodal distribution...

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Sonraí Bibleagrafaíochta
Main Authors: Owen, David R, Yeo, Astrid J, Gunn, Roger N, Song, Kijoung, Wadsworth, Graham, Lewis, Andrew, Rhodes, Chris, Pulford, David J, Bennacef, Idriss, Parker, Christine A, StJean, Pamela L, Cardon, Lon R, Mooser, Vincent E, Matthews, Paul M, Rabiner, Eugenii A, Rubio, Justin P
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2012
Ábhair:
Rapid Communication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323305/
https://ncbi.nlm.nih.gov/pubmed/22008728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.147
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