Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO)()

TSPO mediated transport of cholesterol into the mitochondrion is a necessary step in steroid synthesis. The rs6971 polymorphism in the TSPO gene causes an amino acid substitution (Ala147Thr) within the transmembrane domain where the cholesterol-binding pocket is located, and has been shown to affect...

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Bibliographische Detailangaben
Hauptverfasser: Colasanti, Alessandro, Owen, David R., Grozeva, Detelina, Rabiner, Eugenii A., Matthews, Paul M., Craddock, Nick, Young, Allan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Pergamon Press 2013
Schlagworte:
Short Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820042/
https://ncbi.nlm.nih.gov/pubmed/23942012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psyneuen.2013.07.007
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