Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPA

[(18)F]-FEPPA binds to the 18-kDa translocator protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of the PET signal with new generation TSPO PET radioligands are confounded by large interindividual variability in bi...

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Bibliographic Details
Main Authors: Mizrahi, Romina, Rusjan, Pablo M, Kennedy, James, Pollock, Bruce, Mulsant, Benoit, Suridjan, Ivonne, De Luca, Vincenzo, Wilson, Alan A, Houle, Sylvain
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
Subjects:
Rapid Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367231/
https://ncbi.nlm.nih.gov/pubmed/22472607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.46
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