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Identifying improved TSPO PET imaging probes through biomathematics: The impact of multiple TSPO binding sites in vivo
To date, (11)C-(R)-PK11195 has been the most widely used TSPO PET imaging probe, although it suffers from high non-specific binding and low signal to noise. A significant number of 2nd generation TSPO radioligands have been developed with higher affinity and/or lower non-specific binding, however th...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Academic Press
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3314937/ https://ncbi.nlm.nih.gov/pubmed/22251896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2011.12.078 |
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