Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited

Quantitative estimation of neuroreceptor occupancy by exogenous drugs using positron emission tomography is based on the reduction in the total volume of distribution (V(T)) of site-specific radioligands after drug administration. An estimate of the distribution volume of free and nonspecifically bo...

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Hlavní autoři: Cunningham, Vincent J, Rabiner, Eugenii A, Slifstein, Mark, Laruelle, Marc, Gunn, Roger N
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Brief Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949110/
https://ncbi.nlm.nih.gov/pubmed/19738632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.190
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