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RIM proteins tether Ca(2+)-channels to presynaptic active zones via a direct PDZ-domain interaction
At a synapse, fast synchronous neurotransmitter release requires localization of Ca(2+)-channels to presynaptic active zones. How Ca(2+)-channels are recruited to active zones, however, remains unknown. Using unbiased yeast two-hybrid screens, we here identify a direct interaction of the central PDZ...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063406/ https://ncbi.nlm.nih.gov/pubmed/21241895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.12.029 |
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