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RIM C(2)B domains target presynaptic active zone functions to PIP(2)-containing membranes

Rapid and efficient synaptic vesicle fusion requires a pool of primed vesicles, the nearby tethering of Ca(2+) channels, and the presence of the phospholipid PIP(2) in the target membrane. While the presynaptic active zone mediates the first two requirements, it is unclear how fusion is targeted to...

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Bibliografiske detaljer
Udgivet i:Neuron
Main Authors: de Jong, Arthur PH, Roggero, Carlos M, Ho, Meng-Ru, Wong, Man Yan, Brautigam, Chad A., Rizo, Josep, Kaeser, Pascal S
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910229/
https://ncbi.nlm.nih.gov/pubmed/29606581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.03.011
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