RIM Proteins Activate Vesicle Priming by Reversing Auto-Inhibitory Homodimerization of Munc13

At a synapse, the presynaptic active zone mediates synaptic vesicle exocytosis. RIM proteins are active-zone scaffolding molecules that – among others – mediate vesicle priming, and directly or indirectly interact with most other essential presynaptic proteins. In particular, the Zn(2+)-finger domai...

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Bibliografiske detaljer
Main Authors: Deng, Lunbin, Kaeser, Pascal S., Xu, Wei, Südhof, Thomas C.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063404/
https://ncbi.nlm.nih.gov/pubmed/21262469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.01.005
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