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Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression
Notch signaling plays both oncogenic and tumor suppressor roles, depending on cell type. In contrast to T-cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B-cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3062299/ https://ncbi.nlm.nih.gov/pubmed/21224467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-253419 |
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